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Preventing HIV Transmission -using washed Semen
• Manystudiesreportedsincethen,usingwashedsperm for IUI, IVF, ICSI
• MetaanalysisandSystematicReviewconductedin March 2016, of all studies with:
- primary outcome : HIV transmission to uninfected women.
- secondary outcome : HIV transmission to newborns
- other outcomes : Pregnancies achieved
- setting : All countries
Ref. Maryam Zafer et.al. Fertil Steril 2016 March: 105(3) 645-655
Duru Shah
Meta analysis & Systematic Review
• StudyGroup
Results:-
→40singlearmopenlabelstudies → HIV discordant couples undergoing
fertility treatment.
→ IUI, IVF, ICSI,
→ 11,585 cycles in 3994 women
• NoHIVtransmissiontononinfectedwomen
(95% CI = 0.0001)
• NoHIVtransmissionwithoutviralsuppressionofHIV+ve men at time of semen washing.
Ref. Maryam Zafer et. Fertil Steril 2016 March Contd... Duru Shah
- 2863 cycles in 1023 women (27.1 % of cycles) - (95% CI = 0.0029)
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