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HIV infected male and HIV uninfected female
• Prevent transmission to female partner and fetus • ... Donor sperm
• ...... IUI with washed sperm
• ......... IVF with ICSI
• ............ Male partner on HAART with plasma viral load – not detectable
• Oral Preconception Pre- Exposure HIV prophylaxis (PrEP) to the uninfected female partner.
Ref. Recommendations for Use of Antiretroviral Drugs in Pregnant HIV 1 –Infected Women for Maternal Health and Interventions
to reduce Perinatal HIV Transmission in the United States. https://aidsinfo.nih.gov/guidelines on 5/4/2019
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HIV in Semen
• Unprotected vaginal intercourse
→ 0.1% per act is the transmission rate.
p = <0.001
• First study in 1989 found no HIV transmission with
IUI to 29 uninfected female partners in
HIV discordant couples.
Ref. Semprini AE. et.al. Lancet 1992; 340: 1317-1319
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