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Are all embryos mosaic?
• Should mosaicism be considered a normal part of preimplantation development?
• Results from studies examining all cells of embryos suggest not
Study
Embry o no.
Stage Normal
Aneuploid
Mosaic aneuploid
Mosaic
diploid aneuploid
Wells and Delhanty, 2000
12 Cleavage 3 (25%) 1 (8%) 3 (25%) 5 (42%)
Voullaire et al., 2000
12 Cleavage 3 (25%) 2 (16.5%) 2 (16.5%) 5 (42%)
Fragouli et al., 2011
52 Blastocyst 22 (42.3%) 13 (25%) 8 (15.4%) 9 (17.3%)
Detection of mosaicism
NaCGGSH- d- epfoinssitieblme mosoasicailcoslossosfocfhcrhormomososmome 9e,9also mosaic segmental abnormality on chromosome 5 NGS is the most effective method for detecting mosaic trophectoderm biopsies
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