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Preimplantation genetic testing for aneuploidy (PGT-A)
Embryo biopsy (~5 cells from trophectoderm)
Genetic testing
Euploid embryo transfer
Lower miscarriage, higher implantation, lower Downs risk Fewer unsuccessful embryo transfers, faster time to pregnancy
Preimplantation genetic testing for aneuploidy (PGT-A)
Biopsy must be representative of the embryo This is usually the case.....
Mosaicism
....but not always
Mosaicism most common at cleavage stage Errors in first mitotic divisions
Occasionally, ‘aneuploid’ embryos have been transferred and resulted in a healthy pregnancy
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