Page 54 - ESHRE2019
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Cochrane Review, updated 2018
Haas DM, Hathaway TJ, Ramsey PS
• Meta-analysis: Reduction in miscarriage rate from 26% to 18% with progestogen supplementation
RR 0.69, 95% CI 0.51-0.92
11 RCTs, Moderate quality evidence
– Placebo-controlled vs. non-placebo-controlled: No difference – ≥3 miscarriages vs. ≥2 miscarriages: More pronounced effect
• Meta-analysis: Increased live birth rate from 67% to 74% RR 1.11, 95% CI 1.00-1.24
7 RCTs, Moderate quality evidence
3 trials reported live birth rate: Swyer et al., 1953; Coomarasamy et al., 2015; Ismail et al., 2017
3 RCTs reporting Live Birth Rate
Swyer, Daley. Progesterone implantation in habitual abortion. British Medical Journal 1953
•
Coomarasamy et al., A randomized trial of progesterone in women with recurrent miscarriages.
New England Journal of Medicine, 2015 •M
Ismail et al., Peri-conceptional progesterone in unexplained recurrent miscarriage
Journal of Maternal-Fetal & Neonatal Medicine, 2017 •M
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