Page 108 - ESHRE2019

Detect antibodies that inhibit in vitro phospholipid coagulation reactions
1. Prolongation of a phospholipid dependant clotting test (usually APTT).
2. There should be a relative correlation of the defect by the addition of phospholipids
3. Clotting time of a mixture of test and normal plasma should be longer than the clotting time of normal plasma (how true? Only 25% in our patients).
Interpreting lupus anticoagulant testing using the dilute Russell viper venom (RVV) test
RVV

X Xa 
Prothrombin Thrombin 
Fibrinogen Fibrin
All stages are dependent on phospholipid thus if aPL present , they will remove phospholipid and prolong the clotting time
106
103