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Detecting antiphospholipid antibodies Miyakis et al. J Thromb Haemost 2006; 4: 295-306
• Definition- 2 positive tests on two occasions more than 12 weeks apart
• Either a lupus anticoagulant &/or anticardiolipin antibodies &/or anti-2 glycoprotein I antibodies
• aPL often interfere with other functional thrombophilia assays -Protein C, antithrombin.
• Frequently low free Protein S
Anti-beta2 glycoprotein I adds little to routine testing in patients with previous thrombosis but important in 1) defining those who are “triple positive”
2) pregnancy where a significant subset that are only postivie for anti-beta2 glyocprotein I
Galli Thromb Haemost 2002; 88: 729-32
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