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Mouse Transgenesis: Loss of Function
Phylogeny of zona proteins
ZP1 ZP4 ZP2
ZP3
trefoil
trefoil
ZP1 Zona domain (A) ZP4
Disulfide Bonds
Zona domain (B) ZP3
Zona domain (A)
Disulfide Bonds
ZP2 is the Zona Ligand for Sperm Binding
moZP1 moZP2
Mouse sperm binding
moZP3
huZP4
Hu Mo 2-Cell embryos
Hu Mo 1
Female mice are infertile
2-Cell embryos
20 μm
1
2 33
2 44
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PRECONGRESS COURSE 02 I VIENNA, AUSTRIA – 23 JUNE 2019 57
Anti-mouse mAb
Anti-human mAb
