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Human Sperm Bind* to huZP2 Rescue Zona huZP1 Rescue huZP2 Rescue
Hu Mo 11 22 33 44
Hu Mo Hu Mo 11 22 33 44
Hu Mo
huZP3 Rescue huZP4 Transgenic
*but do not fertilize
Control
Zp2 Null
trefoil
Mouse Transgenesis: Loss of Function
ZP1 Disulfide Bonds
Zona domain (A)
ZP2 Disulfide Bonds
Zona domain (A)
Zona domain (B) ZP3
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