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DNA fragmentation and Semen Analysis
DNA fragmentation can be present in normozoospermic subfertile men and thus in unexplained infertility (Erenpreiss et al., 2008; Oleszczuk et al., 2013).
However, it also coexists with reduced count, increased rates of abnormal forms and reduced
motility, depending on the cause. (Appasamy et al., 2007; Giwercman et al., 2003).
Impact of sperm DNA fragmentation on fertility
• Alters embryonic development:
• Preimplantationembryonicdevelopment(upto8cells) • Firsttrimestermiscarriage
Benchaib M, Lornage J, Mazoyer C, Lejeune H, Salle B, Guerin JF. Sperm deoxyribonucleic acid fragmentation as a prognostic indicator of assisted reproductive technology outcome. Fertil Steril. 2007 Jan;87(1):93-100.
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