Page 54 - ESHRE2019

List of medications for male infertility
• Hormonal treatments
• FSH&hCG/pulsatileGnRH • Anti‐estrogens
• Aromatase inhibitors
• Dopamineagonists
• Testosterone (?)
• Corticosteroids
• Antibiotics
• Anti‐inflammatory therapy • ‐agonists
• PDE‐inhibitors
• Anti‐Oxidants
:Hypogonadotropichypogonadism : Oligospermia
: Oligospermia :Hyperprolactinemia
: NO (hormonal contraception) : Autoimmunization ?
: Infection
: inflammation
: anejaculation
: asthenospermia ? : “Vitamins”
Current issues in male infertility
• Since ICSI (1993), fertilization is
under control.
Van Steirteghem et al. 1993
• The main issue is now the development of embryo and fetus until birth of a healthy baby.
• Male factors involved in embryo development :
• Aneuploidy, • Caryotype
• Sperm DNA integrity • OxidativeStress
• ... ?
52
48