Page 139 - ESHRE2019

HOW TO EXAMINE THE OUTCOME OF ICSI
Difficulty to separate the outcome of the technique
from the genetic and environmental background of the couple
• •
•
•
•
•
•
Comparison to the general population? Comparison to ART children ?
What is the risk of ART vs general population Comparison to children of subfertile parents?
IUI, waiting list
Comparison between sibs after ART and non-ART?
Controlling for maternal age, parity...
ESHRE 2019
26-5-2019 | 9
HOW LONG TO FOLLOW THE CHILDREN?
Preoccupation on short and long-term outcome !
•
•
•
•
ART is completely different compared to spontaneous conception
Hormonal stimulation, manipulation of gametes, embryo culture, vitrification, invasive procedure (ICSI, biopsie embryonnaire)
Barker hypothesis “ developmental plasticity “
Adaptive responses to environmental exposures during critical period of embryonic development  alterations of structures / organic fonctions
ESHRE 2019
26-5-2019 | 10
133
PRECONGRESS COURSE 01 I VIENNA, AUSTRIA – 23 JUNE 2019 137