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WHY Testicular Sperm over Ejaculated Sperm for ICSI (when both are available)
Esteves, 9
Experimental evidence
Suganuma et al, Hum Reprod 2005
Wild-type and mutant mice (sperm DNA damage)
ICSI with sperm from epididymis and testis of mutant and normal mice
Findings:
1.Rates of sperm with damaged chromatin increased as sperm transited through the epididymis, mostly in mutant mice
2.Remarkable decline in fertility of mouse sperm with abnormal chromatin during epididymal passage as revealed by ICSI
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