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Influence of Sperm Parameters
Later ICSI Experience
ICSI outcomes influenced by sperm parameters
Sperm chromatin damage
Greco et al, Hum Reprod 2005
Robinson et al. Hum Reprod 2012
Zhao et al. Fertil Steril 2014
Mehta et al. Fertil Steril 2015
Esteves et al. Fertil Steril 2015
Simon et al. Best Pract Res Clin Obstet Gynaecol 2017 Esteves et al. Fertil Steril 2017
Esteves, 7
ESTEVES, 7
IVF/ICSI: Importance of Sperm DNA Damage
Infertile men often have sperm DNA damage (particularly, men
with poor sperm parameters)) Moskovtsev et al, Urology 2009 Belloc et al, Fertil Steril 2014
Esteves et al, 2015
Sperm DNA damage associated with a lower probability of pregnancy and a higher probability of pregnancy loss
Collins et al, Fertil Steril 2008
Zini et al, Hum Reprod 2008
Simon et al, AJA 2017
Simon et al. Best Pract Res Clin Obstet Gynaecol 2017
Growing concern that an underlying sperm genetic defect could be transferred via ICSI Aitken et al, Nature 2004
Esteves, 8
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