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Fertil Steril (2013) 99:673–7
• Sperm DNA damage is more common in infertile men and may contribute to poor reproductive performance.
• Current methods for assessing sperm DNA integrity do not reliably predict treatment outcomes and cannot be recommended routinely for clinical use.
ESHRE’s SIG in Andrology
• Standardization of clinical assays are required
– Some assays may induce fragmentation
• High quality clinical data is urgently required
Barratt et al. (2010) Hum Reprod. 25(4) 824-38
Overview
• Sperm chromatin structure
• Causes of sperm DNA damage
• Tests for DNA fragmentation
• Effects on IVF outcomes
What can be done?
• What can be done?
• Conclusions
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