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A systematic review and meta‐analysis on effect of sperm DNA damage on IVF and ICSI
• 56 studies involving 8068 treatment cycles
• A strong negative association between sperm DNA damage
and clinical pregnancy after IVF and/or ICSI.
• Determination by TUNEL, Comet, and SCD studies but not SCSA had a negative effect on ART clinical pregnancy.
• A strong negative association between DNA damage and clinical pregnancy was more consistently shown in studies utilizing TUNEL and Comet assays than those utilizing SCSA and SCD assay.
Simon et al. (2016) Asian J Androl 18, 1–11
2016
• 30studiesincluded
• Prediction of ongoing pregnancy rate at 12 weeeks – TUNEL assay (AUC of 0.71; 95% CI 0.66 to 0.74)
– Comet assay (AUC of 0.73; 95% CI 0.19 to 0.97).
– SCSA and the SCD tests (AUC of 0.49)
• Conclusion:spermDNAfragmentationtestshave limited capacity to predict the chance of pregnancy; do not recommend the routine use of tests
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