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Mitochondria in Oocytes
• Large endowment of mitochondria: 100K‐>600K • Round/few cristae in oocytes vs. elongated/many
cristae in morula/blastocyst
• Localizationchangesbasedonstage:
– GV/M‐I perinuclear (to support meiotic activities, spindle formation, chromosomal segregation?)
– More peripheral in M‐II
– Perinuclear at 2‐PN stage
– Transient microzonation
Va Blerkom, RBM Online 2008
Mitochondrial Threshold for Viable Embryo Development in Mice
Spont Ab Failed organogenesis
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PRECONGRESS COURSE 10 I BARCELONA, SPAIN – 1 JULY 2018 73
