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When mitochondria do not function...
http://www.mitocanada.org/about‐mitochondrial‐ disease/what‐are‐the‐signs‐and‐symptoms/
How Do ROS Form in Mitochondria?
• Normally O2 is reduced to H20 through redox reactions
• ~ 0.1–2% of electrons passing through the chain oxygen is prematurely and incompletely reduced to give rise to superoxide radical (*0‐2)
• Thepronatedformhydroxyperoxyl(HO*)inactivates enzymes or initiate lipid peroxidation
Novo and Parola Fibrogenesis & Tissue Repair 2008 1:5 doi:10.1186/1755‐1536‐1‐5
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PRECONGRESS COURSE 10 I BARCELONA, SPAIN – 1 JULY 2018 71
