Page 72 - PCC10
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Mitochondrial Theory of Aging
ROS Generation during Mitochondrial Function
Induces mtDNA Mutations
Accumulation of more mtDNA Mutations
Impaired RedOx Function
Loss of Cellular and Tissue Functions
Mitochondrial Function and Oocyte Quality: Is there a Connection?
Vicious cycle: an exponential increase in oxidative damage during aging
Reduced Energy & Signaling Functions Apoptosis and Cell Senescence
Page 66 of 135
Tilly and Sinclair, Cell Metabolism 2013
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