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Unrelated Donor Searches
• HLA matched unrelated donors = MRD
• Available donors:
– NMDP: > 9.5 million volunteer donors – Worldwide: ~20 million total
– Cord blood: > 550,000
• Chance of finding A, B, DR match: – ~60-80% with one million donors
• Chance best:
– Cauc> Am. Indian> Hisp/Asian> Afr-Amer
Matching for Stem Cell Transplantation HLA Factors
• DNA-based testing methods
• Goal: match 8/8 HLA-A, B, C, DRB1 • All loci equally important
• Match 10/10 A, B, C, DRB1, DQB1? • Allele level matching needed
• Allele mismatch = antigen mismatch • Minimize the number of mismatches
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PRECONGRESS COURSE 10 I BARCELONA, SPAIN – 1 JULY 2018 39