Page 41 - PCC10
P. 41
HLA-C/KIR in reproductive failure
Uterine NK cells express members of the killer immunoglobulin-like receptor (KIR) family that bind to parental HLA-C molecules
on the invading placental trophoblast cells. Different KIR/HLA-C genetic combinations occur in each pregnancy. Because inhibitory KIRs are found more frequently in women with defective placentation,
e.g. pre-eclampsia, fetal growth restriction or recurrent spontaneous abortion, some fertility clinics suggest that women should
be ‘tissue typed’ for their KIR genotypes.
HLA and PGD for HLA-matched sibiling donor
Page 35 of 135
PRECONGRESS COURSE 10 I BARCELONA, SPAIN – 1 JULY 2018 41
