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Hyperinsulinemia adversely affects the periimplantation enviroment
Glycodelin
The endometrium
Hyperinsulinemia adversely affects
endometrial function and the
periimplantation environment by
decreasing expression of glycodelin and
IGF binding protein‐1 (Jakubowicz et al.,JCEM 2001)
In vitro (pioglitazone) improvement of insulin sensitivity promotes extravillous trophoblast cell migration stimulated by IGF‐I ( Mayama et al, End. J. 2013)
Page 164 of 196
Rojas J, Int J Reprod Med 2014
PRECONGRESS COURSE 07 I BARCELONA, SPAIN – 1 JULY 2018 171
