Page 170 - PCC07

Insulin resistance and pregnancy: physiological aspects
Progesterone suppresses the phosphoinositol 3-kinase-mediated pathway by reducing the expression of IRS-1. >>>>increased inhibition insulin-induced GLUT4 translocation and glucose uptake
The role of cytokines
The role of FFA
Sonagra et al. 2014
A potential mechanism for TNF alpha affecting the post receptor insulin signaling cascade in skeletal muscle resulting in decreased insulin sensitivity
Catalano et al., 2010
Insulin resistance and pregnancy: pathological aspects
PCOS
 represents per se a risk factor for the development of pregnancy complications
Devlieger R, Acta Obstet Gynecol Scand 2008
Pre‐existing insulin resistance:
 may unmask a condition of relative beta‐cell insufficiency
obesity
physical inactivity race
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Increase of beta cells mass with increased insulin biosynthesis and enhanced glucose- stimulated insulin secretion
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