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Metabolic Comparisons Of PCOS vs Control Oocytes During IVM
• PCOS significantly associated with increased oocyte glucose and pyruvate consumption and reduced lactate production
• PCOS different to PCO
• Higher pyruvate consumption associated with abnormal
oocyte karyotype
• Metformin therapy attenuated pyruvate metabolism
Harris, Maruthini , Tang, Balen & Picton. Human Reproduction 2010; 25: 2305-15
Optimum oocyte yield for livebirth
Live birth rate and oocyte yield
35
30
25
20
15
10
5 0
1 3 5 7 9 11 13 15 17 19 21 23 25 Oocyte number
Overstimulation may:
Over-expose follicles + endometrium to deleterious factors
Interfere with natural selection
of good quality oocytes and increase aneuploidy & epigenetic abnormalities
Van der Gaast et al, RBM Online, 2006; 13:476 Baart et al Hum Reprod 2007; 22:980 Heijnen et al Lancet 2007; 369:743
Optimal
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LBR