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IVF for PCOS
• Last resort in management of anovulatory infertility • May be required if co-existent male factor, tubal
infertility etc...
• Remember presence of polycystic ovarian morphology (PCOM) in the absence of symptoms of PCOS
Oocytes from polycystic ovaries
Paracrine dysregulation of growth factors
may disrupt intrafollicular environment,
alter granulosa cell – cumulus - oocyte interactions
and impair cytoplasmic and nuclear maturation of oocytes
 developmental competence  ability to complete meiosis
Chromosomal pre-division in oocytes from PCOS (premature separation of sister chromatids)
 fertilization
 development into a normal embryo
Rice et al, 2005 Dumesic et al, 2008 Weghofer et al, 2007 Harris et al, 2010 Maruthini et al, 2014
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