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Why is Letrozole better than Clomiphene?
l Aromatase inhibition achieves a more favorable ovulation/conception/implantation environment
u Lower estradiol, higher progesterone after ovulation
u Lowers number of small follicles in the ovary (and their hormone-Anti-Mullerian Hormone) with treatment
u Endometrium is thinner with letrozole
– Probably not an important predictive parameter
Infertile PCOS
Obese Nonobese
Lifestyle therapy Clomiphene
Letrozole
Clomiphene
Letrozole
Hum Reprod. 2008 Mar;23(3):462-77 and Fertil Steril. 2008 Mar;89(3):505-22
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PRECONGRESS COURSE 07 I BARCELONA, SPAIN – 1 JULY 2018 107