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Significant Change in Key Parameters at Final Midluteal Visit
Parameter
Change with Letrozole Relative to Clomiphene
Antral Follicle Count and AMH Level
Decreased
Endometrial Thickness
Decreased
Estradiol
Decreased
Free Androgen Index
Decreased
Progesterone
Increased
Significant Change in Key Parameters During
Study mean (S.D.) [25%, 75% percentiles]
Legro et al, NEJM, 2014
Category
Change in Measure from Baseline to Last Midluteal Visit
Clomiphene
Letrozole
P Value*
Ultrasound
Antral follicle count (both ovaries)
-3 (23) [-12, 8]
-5 (22) [-16, 5]
0.036
Endometrial thickness: sagittal plane (mm)
3 (4) [1, 6]
2 (4) [0, 5]
<0.001
Serum
Estradiol (pg/mL)
53 (108) [-2, 92]
9 (60) [-21, 33]
<0.001
Progesterone (ng/dL)
11 (22) [-0.1, 15]
13 (21) [0.1, 18]
<0.001
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