Page 49 - PCC03

microRNAs as potential serum markers for endometriosis – published examples for specificity and sensitivity
– combination miR-16,-191 and 195: Sensitivity:88%, Specificity:60% – Let-7d (proliferative phase): Sensitivity: 83,3%; Specificity: 100%
– miR145*: Sensitivity: 70%; Specificity: 96%
– miR-200a: Sensitivity: 90,6%; Specificity: 62,5%
Ahn S et al. Fertil Steril 2017, Nisenblat V et al. Cochrane Database Syst Rev. 2016
„While several microRNAs show some promise as diagnostic markers for endometriosis, the two published studies identified completely independent microRNA biomarkers. These results require further validation in a large, well-defined population with a wide spectrum of disease, using a standardised reproducible methodology.“
microRNAs in endometriosis | Prof. Dr. Martin Götte
microRNAs as noninvasive biomarkers
Agrawal S et al. The miRNA Mirage: How Close Are We to Finding a Non-Invasive Diagnostic Biomarker in Endometriosis? A Systematic Review. Int J Mol Sci. 2018 Feb 17;19(2).
– Nine studies were critically analysed, and 42 different miRNAs were found to be dysregulated in them, with only one common miRNA (miR- 20a) differentially expressed in more than one study. miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis.
– „The disagreement between the various studies upholds the demand of larger, well-controlled systematic validation studies with uniformity in the research approaches and involving diverse populations.“
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Non-invasive biomarkers | Prof. Dr. Martin Götte
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