Page 26 - PCC02

Blood products in ART media
• Issuesandchallenges – Maternal serum
• Dependent on nutritional and medical/physiological status – Donor serum
• Cases with transmission of infectious diseases – “TheRotterdamcase”,hepatitisB
– Fractionated serum/plasma
• Commercially available blood products
– Bovine serum albumin – difficult after the BSE crisis – Human serum albumin
» Not made for ART
• Difficult to source hSA that work well in ART
Human serum albumin
• Pleiotrophic molecule
– May regulate
• pHandosmolality
– May donate • Lipids
• Carboxylicacids
• SteroidsandThyroxin – May adsorb
• Lipophilic contaminants
– Major contributor to batch‐ to‐batch variation
26
Page 20 of 151