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  Endocrine disruptors:
Some endocrine disruptors from « current life »: Note the structural analogies with Estradiol
 On BPA substitutes
 The link between oxidative stress and methylation disturbance: Xenobiotics (EDCs) interactions with some receptors
ERs ARs: estrogen, androgen receptor
PPAR: proliferator of activated peroxisomes Receptors
Constitutive androstane receptor (CAR), Pregnan X receptor (PXR), Ah: Aryl carbon receptor
 XENOBIOTICS (EDs)
     ERs, ARs
(Sex) Hormonal pathologies
PPAR
Brain diseases???
AhR, PXR,CAR
       Stress Ox ++ Methylation ‐‐
Stress Ox ++ Methylation ‐‐
  Obesity is not only a matter of food consumption
Endocrine pathologies Diabetes, obesity....
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