Page 112 - PCC02

Guanine is the base the most sensitive to oxidation. But not the only one
Poly-insaturated fatty acid
CH3 (CH2)n
COOH
COOH
O
O
OH
2,3-epoxy-4-HNE
O H N H N N N N
(CH2)n
OO°
(CH2)n
O OH
4-hydroxynonenal
OH O H OH N N
O°
O°
Poly‐insaturated Fatty acid
CH3 (CH2)n
OO HH
Malonaldehyde
O
N
H N
NN
N
MDA‐Gua (M1G)
NNN HNNNNN
H 1,N2-Gua 1,N6-Ade 4-HNE-Gua
Badouard et Menezo 2007
112
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