Page 116 - Eshre 2018
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Sperm non‐coding RNAs: functions beyond spermatogenesis?
Epigenetic inheritance via paternal germline
Environmental/lifestyle factors may change the epigenome of spermatozoa, these changes can be transmitted to next generations in fertilization.
Environment / lifestyle insult • Toxins
• Endocrine disrupters
• Smoking
• Obesity • Stress
Insult affects sperm epigenome during spermatogenesis or sperm maturation
Altered gene expression in zygote
Impaired embryo growth and health of offspring
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