Page 114 - Eshre 2018
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Nonsense‐mediated mRNA decay (NMD) and SMG6
SMG6
Endonuclease that initiates the degradation of NMD substrates
Ubiquitously expressed, in male germ cells localizes to the CB
SMG6-mediated cleavage
Exonucleolytic decay from internal sites
SMG6
DDX25
MERGE
10μm
Deadenylation and/or decapping followed by exonucleolytic decay
0
SMG6 knockout male mice are infertile
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