Page 112 - Eshre 2018
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Transcriptional activity during spermatogenesis
Active transcription
Very active, widespread transcription of the genome
Cease of transcriptional activity
Mature spermatozoa are transcriptionally inactive
BIRTH
Primordial germ cell
Spermatogonium
Primary Spermatocyte
Secondary Spermatocyte
Round Spermatid (haploid)
Spermatozoon (haploid)
PROLIFERARATION
MEIOSIS
HAPLOID DIFFERENTIAION
mitotic divisions
mRNAs
piRNAs
lncRNAs intergenic
MEIOSIS I MEIOSIS II
CHROMATOID BODY
Male germ cell –specific cytoplasmic RNP granules (germ granules)
Intermitochondrial cement (IMC, green)
• Prominentinpachytenespermatocytes
Chromatoid body (CB, pink)
• Startsfrominginlatespermatocytes,onebig granule in round spermatids
IMC CB
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