Page 108 - Eshre 2018
P. 108
Transcriptional activity during spermatogenesis
Active transcription
Very active, widespread transcription of the genome
Cease of transcriptional activity
Mature spermatozoa are transcriptionally inactive
BIRTH
Primordial germ cell
Spermatogonium
Primary Spermatocyte
Secondary Spermatocyte
Round Spermatid (haploid)
Spermatozoon (haploid)
PROLIFERARATION
MEIOSIS
HAPLOID DIFFERENTIAION
mitotic divisions
MEIOSIS I MEIOSIS II
Germ cells have exceptionally diverse transcriptomes
• Transcription of the genome is substantially more widespread in the testis than in other organs.
• Meiotic spermatocytes and especially postmeiotic round spermatids have remarkably diverse transcriptomes, which explains the high transcriptome complexity of the testis as a whole.
• The widespread transcription encompasses protein-coding and long non-coding RNA genes but also poorly conserves intergenic sequences.
Soumillon et al. Cell Reports, 2013
108
Page 102 of 130
