Page 95 - PRECONGRESS COURSE 06

The administration of LH activity in COS
The physiologic role of LH during the follicular phase of a natural cycle is unquestionable
its impact during a COS cycle remains controversial Balasch et al 1995
The administration of LH activity in COS induces an LH dose‐dependent increase of
follicular fluid E2, Androstendione, and Testosterone Bosch et al 2006
Oocytes with multiple anomalies were recovered from follicles
with significantly higher LH levels. Bosch et al 2006
Metanalysis on r‐LH addition
29
van Wely M et al 2003 Baruffi et al 2007 Kolibianakis et al. 2007 Oliveira et al 2007
Mochtar et al. 2007 Hill et al. 2012
MAIN RESULTS
6 RCTs n=2030
5 RCTs n=434
7RCTs n=701
4 RCT’S n=1227
14 trials n=2612
3 trials n=310 POR
7 RCTs n=902 age >35yo
Higher CPR
(RR 1.18; 95% CI 1.02–1.36
Similar CPR
OR:0.89, 95% CI 0.57‐1.39;P = 0.69
Similar LBR
OR: 0.92, 95% CI:0.65–1.31; P 0.65
Similar CPR
OR:1.1, 95% CI: 0.85, 1.42; P=0.52
Similar CPR
OR 1.15, 95% CI 0.91‐1.45 Higher CPR
OR 1.85; 95% CI 1.10– 3.11)
Higher CPR
OR 1.37, 95% CI 1.03–1.83
30
Page 91 of 258
PRECONGRESS COURSE 06 I GENEVA, SWITZERLAND – 2 JULY 2017 95