Page 128 - PRECONGRESS COURSE 06

Mid-luteal progesterone and ongoing pregnancy Lessons learned from GnRHa trigger
GnRHa trigger
Study
Progesterone OPU + 7 (nmol/l)
Positive HCG per ET %
Pregnancy loss %
Clinical pregnancy
Luteal phase support
Humaidan et al., 2005
39±30
29 (14/48)
79 (11/14)
6 (3/48)
vaginal gel progesterone (90 mg/day)
Humaidan et al., 2010
74±52
48 (63/130)
21 (13/63)
38 (50/130)
1500 IU hCG on the day of OPU plus vaginal gel progesterone 90 mg per day
Humaidan et al., 2013
440±25
43 (47/110)
9 (4/47)
39 (43/110)
1500 IU hCG on day of OPU plus OPU+5 days plus vaginal gel progesterone 90 mg/day
P EPL
•
• •
> 25 follicles
Freeze all
Standard luteal phase support: Micronized vaginal progesterone, 90 mg x 2 daily Adapted from Humaidan et al., 2006, 2009, 2010, 2013 26
Individualized LPS (iLPS) after GnRHa trigger - 2017
Day of oocyte pick-up (OPU) – follicles ≥ 12 mm
< 10 follicles
1500 IU hCG at OPU & 1500 OPU+5 + Standard luteal phase support
10 – 14 follicles
1500 IU hCG at OPU + 500 IU OPU + 5 + Standard luteal phase support
15 - 25 follicles
1500 IU hCG at OPU + Standard luteal phase support
•
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