Page 73 - PRECONGRESS COURSE 04
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Learning objectives
• Evolutionary perspective on implantation types: uterine gene expression as a primary driver
• Embryo selection in vivo and in vitro
• Distinguish recurrent implantation failure from recurrent
• Histology of the first 4 weeks of pregnancy
• Functions of endometrial layers with respect to implantation stages
• The multi‐level hypothesis of endometrial receptivity: ‐ epithelial adhesion and displacement
‐ epithelial‐embryo signalling
‐ stromal receptivity & why decidualise? ‐ vascular receptivity & inflammatory cells
miscarriage
Implantation biology and placental form have been defined by uterine evolutionary change
Ancient transposable elements transformed the uterine regulatory landscape and transcriptome during the evolution of mammalian pregnancy. Lynch et al, Cell Rep. 2015;10(4):551‐61. doi: 10.1016/j.celrep.2014.12.052. PMID: 25640180
PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 73
