Page 69 - PRECONGRESS COURSE 04

In-vitro models to study endometrial receptivity
Boggavarapu et al., Contraception 94:143–151 (2016)
Analysis of embryo attachment
control + mifepristone (0.05 μM)
Nr. of blastocysts cultured Nr. of blastocysts attached
+ mifepristone (0.5 μM)
Endometrial receptivity markers regulated by by mifepristone treatment (qPCR)
down‐regulated
FOXO1 FGF2 HAND2 VEGFA HOXA10 PRL
LIF IGFBP1 OPN
University Hospital Essen - Prof. Dr. Ruth Grümmer
up‐regulated
COUP‐TFII IL6
Extracellular vesicles (EVs)
ESHRE 2017 - Geneva
embryo‐derived EVs endometrium‐derived EVs
embryo‐endometrial interactions
• Endometrial EV profile may change during receptivity
• Endometrial receptivity may be modulated by embryo‐derived EVs
University Hospital Essen - Prof. Dr. Ruth Grümmer ESHRE 2017 - Geneva
PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 69