Page 61 - PRECONGRESS COURSE 04

What is the function of genes induced during the receptive phase?
Knockout mouse models
University Hospital Essen - Prof. Dr. Ruth Grümmer ESHRE 2017 - Geneva
Knockout mice to study endometrial receptivity
knockout mice
IL-1RtI
Slight reduction in litter sizes
LIF
impaired implantation and decidualization
IL-11Ra
impaired implantation and decidualization
COX-2
Defects in ovulation, fertilization, implantation, and decidualization
MMP-3, -7, -9
Smaller litter sizes and reduced pregnancy rates
TIMP-1
Smaller litter sizes and reduced pregnancy rates
ERa
impaired implantation
PR
impaired implantation and decidualization
Hmx3
impaired implantation
Hoxa-10
impaired implantation and decidualization
Hoxa-11
impaired implantation and decidualization
Fkbp4
impaired implantation and decidualization
Klf9
impaired implantation and decidualization
Ncoa1
impaired implantation and decidualization
Bsg
Impaired fertilization and implantation
Gp130
no implantation
Ptgs2
impaired decidualization
Pla2g4a
delayed implantation; aberrant embryo spacing
conditional knockout mice
University Hospital Essen - Prof. Dr. Ruth Grümmer
Summarizedin: Pariaetal.,(2001) Lee et al., (2007)
Sharma et al., (2006)
ESHRE 2017 - Geneva
Ncoa2
impaired implantation and decidualization
Ihh
impaired implantation and decidualization
PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 61