Page 65 - PRECONGRESS COURSE 03

FERTILIZATION
STATUS OF THE FIELD
• How do we know?
• Animal models
• IVF
• Basic research and clinical experiences
• What still not known?
• Species differences
• In vitro vs. in vivo
• Molecular details and comprehensive understanding
• Why need to know more?
• To extend knowledge from animal studies to human • For optimization of IVF conditions
• For non-hormonal contraceptive targets
• For diagnosis, management, and treatments of fertilization failure cases
FERTILIZATION FAILURES
DIFFERENT LEVELS
• Few failed-to-fertilize oocytes within a cohort • ~1-20%failure
• routine occurrence
• Partial fertilization failures
• ~20-99%failure
• low to moderate to high categorizations
• Total fertilization failures (TFF) • 100%failure
• 5-16% of cycles after IVF
• ~1-5% of cycles after ICSI
• sporadic vs. recurrent cases
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PRECONGRESS COURSE 03 I GENEVA, SWITZERLAND – 2 JULY 2017 65