Page 64 - PRECONGRESS COURSE 03
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FERTILIZATION
INITIAL EVENTS
• Sperm-oocyte interactions
• Cumulus cells → zona pellucida → oolemma • Acrosome reaction
• Sperm-oocyte fusion
A CASCADE OF RESPONSES IS TRIGGERED AT ’EGG ACTIVATION’
• Sperm entry
• Calcium oscillations
• Zinc sparks
• Block to polyspermy
• Resumption and completion of female meiosis • Global changes in RNAs and proteins
• PN formation
• PN migration
• PN apposition
• Egg activation
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