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Non‐aligned bivalents do not slow down cyclin B1 degradation (=APC activity)
Max. cyclin B1
Min. cyclin B1
D
100
80
60
40
20
0
Aligned (n=8) Non-aligned (n=8)
n.s. 50 (8) (8)
40 30 20 10
0 yes no Alignment
Lane et al Development 2012
3 4 5 6 7 8 9 10
Time after NEB (hours)
The Spindle Assembly Checkpoint
Mitotic like function (with a little twist).
a. Bivalents with errors can’t stop MI division.
b. Not switch‐like (OXN‐ OFF not correct)
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PRECONGRESS COURSE 03 I GENEVA, SWITZERLAND – 2 JULY 2017 31
Cyclin B1-Venus (% of max)
Max Cyclin B1‐Venus (%/h)
Max CylinB1-Venus (%/h)
