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What about sperm function tests?
→ Sperm function tests have the potential to assist the clinician in the decision-making process.
→ Need for standardization of methodologies → Most valuable tests
Sperm penetration assay Sperm-zona pellucida binding tests Acrosome reaction
Hyaluronan binding assay
Oehninger et al. Sperm functional tests. Fertil Steril. 2014;102:1528‐33.
What about DNA fragmentation ?
DNA fragmentation: happens during normal spermatogenesis Sperm DNA damage can cause male subfertility
Oxidative stress is an important source of DNA damage Different methods of detection
Reproductive consequences: only associations / mostly not evidence- based
Target group for testing in a clinical setting remains unclear: repeated ART failure? repeated miscarriage?
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