Page 126 - PRECONGRESS COURSE 01
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DNA fragmentation
Presence of single and double DNA strand breaks is common in the ejaculate
May affect a high percentage of spermatozoa Relevant in infertile/subfertile men
Origin of Sperm DNA fragmentation (sDF): Three theories
• abortiveapoptosis(derangementof spermatogenesis)
• Defects in chromatin maturation (histone to protamine transition)
• Oxidativeattack
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