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1q17q hESCs showed increased proliferation
Naive WT
Naive 1q17q
UGENT11‐60 WT UGENT11‐60 1q17q
Primed Primed 1q17q
Learning Objectives
Chromosomal instability in human pluripotent stem cells:
• Type and frequency of chromosomal abnormalities in hiPSCs and hESCs • Mechanisms leading to chromosomal instability hPSCs
• Culture heterogeneity
• Exogenous effects on chromosomal stability
• Implications for clinical applications
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