Page 71 - ESHRE2019

Mechanisms leading to chromosomal instability and the tumorigenic potential of hPSCs
Similar aberration observed between hPSC and embryonal carcinoma cells
Amplification of 20q11.21 also commonly duplicated in a number of cancers
Chr17 gain is a common instability in many cancers Conserved gene expression networks
Mechanisms leading to chromosomal instability in hPSCs Whole chromosomal gains -> more commonly a result of mitotic errors
Structural rearrangements and unbalanced translocations  occur via non-homologous recombination Spindle Assembly Checkpoint components have been shown to contribute to mitotic errors in hESCs
Knoepfler, Stem Cells, 2009
66
PRECONGRESS COURSE 13 I VIENNA, AUSTRIA – 23 JUNE 2019 69