Page 50 - ESHRE2019
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-However, low efficiency and aneuploid zygotes
•Generation of in vitro primordial germ cell-like cells from mES and miPS through epiblast-like cells having normal global transcription profiles, epigenetic reprogramming,and cellular dynamics.
•To form an in vitro reconstituted ovary after aggregation of disgregated fetal ovary with these PGCLCs.
•Normal meiosis progression after transplantation of these aggregates into an ovary.
• Healthy offspring with normal methylation patterns of imprinted genes.
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