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Human induced pluripotent stem cells
Reports from the laboratories of Thomson (Yu and Thomson, Science 2007), Yamanaka ( Takahashi and Yamanaka, Cell 2007),
Daley (Park, Nature 2008) and
Plath (Lawry and Plath, 2008)
Reproduced the iPS phenomenon in human dermal fibroblasts by ectopic expression of four embryonic stem cell specific transcription factors.
Significance of the Yamanaka Experiment:
differentiated cell
Oct4 Sox2 Klf4 C‐Myc
SCNT oocyte
Found 4 reprogramming factors capable of extreme cellular transition: Fibroblasts to ES‐like cells
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PRECONGRESS COURSE 13 I VIENNA, AUSTRIA – 23 JUNE 2019 13