Page 149 - ESHRE2019

References
Segeritz CP, Rashid ST, Cardoso de Brito M, Paola MS, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan N, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA*, Vallier L* (2018). hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1‐antitrypsin deficiency. J Hepatol. 2018 Jun 4. pii: S0168‐8278(18)32113‐5. doi: 10.1016/j.jhep.2018.05.028. PMID: 29879455. *joint authorship
Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL 3rd, de Brito MC, Berntsen NL, Gómez‐Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander GJ, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, Melum E, Markaki AE, Saeb‐Parsy K*, Vallier L*. (2017). Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine. 2017 Jul 3. doi: 10.1038/nm.4360. PMID: 28671689. *joint authorship.
Sampaziotis F, Cardoso de Brito M, Madrigal P, Bertero A, Saeb‐Parsy K, Soares FAC, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WTH, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF* and Vallier L* (2015). Human Induced Pluripotent Stem Cell derived cholangiocytes for disease modeling and drug validation. Nature Biotechnology. Aug;33(8):845‐52. doi: 10.1038/nbt.3275. *joint authorship
Gieseck Iii RL, Hannan NR, Bort R, Hanley NA, Drake RA, Cameron GW, Wynn TA, Vallier L. (2014) Maturation of Induced Pluripotent Stem Cell Derived Hepatocytes by 3D‐ Culture. PLoS One. Jan 22;9(1):e86372. doi: 10.1371/journal.pone.0086372
Hannan N, Segeritz CP, Touboul T, Vallier L. (2013) Production of hepatocyte like cells from human pluripotent stem cells. Nature Protocols. Feb;8(2):430‐7.
Yusa K*, Rashid ST*, Strick‐Marchand H, Varela I, Liu PQ, Paschon DE, Miranda E, Ordóñez A, Hannan N, Rouhani FJ, Darche S, Alexander G, Marciniak SJ, Fusaki N, Hasegawa M, Holmes MC, Di Santo JP, Lomas DA*, Bradley A* and Vallier L* (2011). Targeted gene correction of α1‐antitrypsin deficiency in induced pluripotent stem cells. Nature. 2011 Oct 12;478(7369):391‐4. doi: 10.1038/nature10424. *joint authorship.
Rashid ST, Corbineau S, Hannan N, Marciniak SJ, Miranda E, Alexander G, Huang – Doran I, Ahrlund‐ Richter L, Skepper J, Griffin J, Semple R, Weber A, Lomas DA, Vallier L. (2010) Modelling inherited metabolic disorders of the liver with human induced pluripotent stem cells. Journal of Clinical Investigations. J Clin Invest. 2010 Sep 1;120(9):3127‐36.
Touboul T, Hannan N, Corbineau S, Martinez A, Martinet C, Branchereau S, Mainot S, Strick‐Marchand H, Pedersen R, Di Santo J, Weber A and Vallier L. (2010). Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions which recapitulate liver development. Hepatology. 51(5):1754‐65.
Acknowledgements
Past Members
‐Sheik Tamir Rashid (PI) ‐ Thomas Touboul (PD) ‐ Adrian Teo (PI)
‐ Lay Tang Ang (PD)
‐ Mina Brimpari (PD)
‐ Candy Cho (PD)
‐ Charis Segeritz (Industry)
‐ Fiona Docherty (PD)
‐ Nick Hannan (PI)
‐ Filipa Soares (Industry)
‐ Sasha Medjan (PI)
‐ Richard Gieseck (PI, Industry) ‐ Siim Pauklin (PI)
‐ Kim Jee Goe (PD)
‐ Pedro Madrigal (PD)
‐ Casey Rimland (Clinical School) ‐ Crystal Chia (PD)
‐ Loukia Yiangiou
Carola Morell
And also:
Stephanie Brown Rodrigo Grandy Samantha Tilson
BRC hIPSC core Facility
An‐Sofie Lenearts Juned Kadiwala Paulina Materek Kirsten Snidjers
Collaborators:
Imperial College Jorge Ferrer Ines Cebola Santi Rodriguez
Exeter University Andrew Hattersley
Manchester University Neil Hanley
Aberdeen University Kevin Docherty
ASTAR Singapore Ray Dunn
KCL
Tamir Rashid
UCL
David Lomas
Cambridge
Koursoh Saeb-Parsy (Surgery) A.Markaki (Engineeering)
Alex Justin (Engineering)
Sanger
Sara Teichmann Chichau Miau
Newcastle Muzz Hanifa
NIH/pFIZER Tom Wyn
Alexander Ross
144
PRECONGRESS COURSE 13 I VIENNA, AUSTRIA – 23 JUNE 2019 147